01 - Preheat oven to 400°F and line a baking sheet with parchment paper or aluminum foil.
02 - In a small bowl, combine olive oil with Cajun seasoning, smoked paprika, salt, black pepper, garlic powder, onion powder, and cayenne pepper until well blended.
03 - Pat salmon fillets dry with paper towels and place them skin-side down on the prepared baking sheet.
04 - Brush the Cajun spice mixture evenly over each salmon fillet, coating the top and sides thoroughly.
05 - Bake for 12–15 minutes, or until the salmon flakes easily with a fork and reaches an internal temperature of 145°F.
06 - Remove from the oven, garnish with chopped parsley or cilantro, and serve immediately with lemon wedges.